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KMID : 0882420130850060551
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Korean Journal of Medicine
2013 Volume.85 No. 6 p.551 ~ p.558
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Pathophysiology of Colon Diverticulum
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Kim Seong-Eun
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Abstract
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Although the pathogenesis of diverticulum remains unclear, traditionally it has been thought to result from structural abnormalities of the colonic wall, deficiencies of dietary fiber, or disordered intestinal motility. More recently, new pathophysiologic factors including inflammation, gut flora, neurotransmitters, visceral hypersensitivity, and chemical mediators are proposed, and their mechanism of interactions in developing diverticulum is quite complex and currently poorly understood. Future studies are needed to find out the multifaceted pathogenesis of diverticulum, ultimately for the treatment and prevention of disease.
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KEYWORD
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Diverticulum, Colon, Pathogenesis
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